Acides aminés (AA)

Applications 6-Methyl-2-heptanol is an intermediate used to prepare tri- and tetrasubstituted imidazoles as highly potent and specific ATP-​mimetic inhibitors of p38 MAP kinase.
References Laufer, S., et al.: J. Med. Chem., 51, 4122 (2008)

Applications Labelled DL-Pipecolinic Acid (P479762). Pipecolic acid is involved in synaptic transmission in the central nervous system.
References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),

Stability Hygroscopic
Applications 2-Fluoro-4-methylphenylboronic Acid (cas# 170981-26-7) is a compound useful in organic synthesis.

Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)

Applications 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid is used in the synthesis of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Also used in the synthesis of 4-carboxamide derivatives acting as antifungal agents.
References Cheng, G. et al.: Bioorg. Med. Chem. Lett., 23, 2035 (2013); Wu, Z. et al.: Molecules, 17, 14205 (2012);

Applications L-Hydroxyprolylglycine_x000D__x000D (cas# 7672-35-7) is a useful research chemical.

Applications N-Methyl-N-trimethylsilylacetamide, is a powerful silylating agent for polar compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Melanie MacGregor-Ramiasa et. al; Acta biomaterialia, 56, undefined (2017-2-25)

Stability Hygroscopic
Applications A metabolite of Catecholamines.
References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)

Applications DL-2-aminobutyric acid

Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.

Stability Hygroscopic
Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.
References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),

Applications α-methyl-DL-tryptophan is used as a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer. It is also a substrate or non-transported inhibitor of the amino acid transporter PAT2 (slc36a2).
References Karunakaran, J., et al.: J. Biochem., 414, 343 (2008); Edwards, N., et al.: Biochimica et Biophysica Acta, Biomembranes, 1808, 260 (2011)

Applications Caerulein is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. It is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.
References Anastasi,E., et al.: Ep., 23, 699 (1997); De Caro, G., et al.: Br. J. Pharmac Chemother., 33, 48 (1968)

Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.
References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);

Stability Hygroscopic
Applications N-Acetyl-S-(2-cyanoethyl)-L-cysteine Ammonium Salt is a metabolite of Acrylonitrile (AN) and acrylamide (AM); and are commonly used in the synthesis of plastics and polymers.
References van Bladeren, P., et al.: Drug Metab. Dispos., 9, 246 (1981), Guengerich, F., et al.: Chem. Res. Toxicol., 4, 168 (1991),

Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.

Stability Hygroscopic
Applications Guaiacol-beta-D-glucopyranoside-d3, is a labeled analogue of Guaiacol-beta-D-glucopyranoside (G245565), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.
References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);

Applications Bis(4-methylpentyl) Phthalate, is a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. It is also the product of the fermentation of Streptomyces regnesis 099.

Applications L-Theanine-d5 (N-ethyl-d5) (CAS# 1217451-85-8) is the labelled version of L-Theanine (T340500(P)), which is a non-protein amino acid mainly found naturally in the green tea plant. It may have activity in modulating the metabolism of cancer chemotherapeutics agents.
References Yokohoshi, H., et al.: Neurochem Res., 23, 667 (1998), Sugiyama, T., et al.: Clin Cancer Res., 5, 413 (1999)

Applications 3-(4-Methylphenyl)-3-(trifluoromethyl)diaziridine (cas# 87736-82-1) is a compound useful in organic synthesis.

Applications N-(1H-pyrrol-2-ylcarbonyl)-Glycine has been used as a diagnostic marker of hyperprolinemia type II.
References Walker, V., et al.: Clinica Chimica Acta, 405, 153 (2009).

Applications 7-Chloro-8-methylquinoline (cas# 78941-93-2) is a compound useful in organic synthesis.

Applications L-Lysine-3,3,4,4,5,5,6,6-d8 Dihydrochloride, is the labelled L-Lysine, a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.
References Rocha, B. et al.: J. Prot. Res., 11, 5350 (2012); Kumar, D. et al.: Polym. J., 45, 160 (2013);

Stability Temperature Sensitive
Applications Methyl 2,3,4-Tri-O-isobutyryl-D-glucopyranuronate (cas# 1190403-86-1) is a compound useful in organic synthesis.

Applications 3-Chloro-2-methyl-1-propene has been used in the synthesis of 2-S-substituted pyrimidines as antimetabolites of nucleic acid precursors for cancer therapy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kaldrikyan, M.A., Melik-Ohanjanyan, R.G.: Hayastani Kimiakan Handes, 67, 321 (2014)

Stability Volatile
Applications 1-Chloro-2-methylpropene is a reagent in the synthesis of pyrrolyl and indolyl diketo acids and esters as nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Costi, R., et al.: J. Med. Chem., 56, 7431 (2013);

Applications L-Lysine-2,6,6-d3 HCl is a useful isotopically labeled compound of L-Lysine HydrochlorideDISCONTINUED PLEASE SEE L486915 (L468923)

Applications Dimethyl L-Aspartate Hydrochloride was used in the synthesis of enzyme and pH dual responsive L-amino acid based biodegradable polymer nanocarrier that can be used for multidrug delivery to cancer cells.
References Saxena, S., et al.: J. Polym. Sci. Pol. Chem., 54, 3279 (2016);

Applications N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.
References Lopez, B., et al.: Chem. Commun., 47, 1054 (2011); Albert, J., et al.: Organometallics, 32, 649 (2013);

Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.
References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)