Protéines

RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a

TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.

Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family.

EGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells.

TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599.

Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family.

IL-5 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag.

CNTF Protein, Human, Recombinant (His) is expressed in E.

IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

BMP-4 Protein, Human, Recombinant (E399D) is expressed in E.

FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family.

BTLA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated

Human serum albumin (HSA), the most prominent protein in plasma, binds different classes of ligands at multiple sites.

<p>GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells.</p>

Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT.

BMP-2 Protein, Human, Mouse, Rat, Rhesus, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.

<p>Full antagonist to the estrogen beta receptor (ERβ) with 36-fold selectivity for the β over α receptor. ERβ is a tumour suppressor and PHTPP is a useful tool to study the biology of estrogen-dependent tumours.</p>

<p>The racemic mixture of cis-trans isomers of clomiphene citrate The cis-isomer, now termed zuclomiphene, is more estrogenic, while the trans-isomer, presently known as enclomiphene, is relatively anti-estrogenic. The racemic mixture utilized for ovulation induction typically contains 38% zuclomiphene and 62% enclomiphene.</p>

Fulvestrant is an estrogen receptor antagonist that is used in the treatment of HR+ breast cancer. This drug can be used as monotherapy or in combination with Alpelisib. Fulvestrant works both by down-regulating and by degrading the estrogen receptor.

<p>Farnesoid X receptor agonist</p>

Glucocorticoid receptor agonist

<p>Estrogen receptor alpha (ERα) agonist</p>

<p>Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.</p>

<p>Ciprofibrate is a fibrate drug that is used as a lipid-lowering agent. This drug reduces both LDL and VLDL cholesterol levels in the blood. Ciprofibrate works by reducing the production of triglycerides in the liver and increasing the removal of triglycerides from the blood. This drug is an agonist of peroxisome proliferator-activated receptor alpha.</p>

<p>Gestodene is a progestogen hormonal contraceptive. It is an agonist of the progesterone receptor. Additionally, this drug is used in menopausal hormone therapy.</p>

<p>Bezafibrate is an antilipemic agent that is used in the management of primary and secondary hyperlipidaemia. This mechanism of action for this drug is not well known however it is generally accepted that this drug is an agonist of Peroxisome proliferator-activated receptor (PPAR-alpha). This drug aids in lowering cholesterol level and triglycerides.</p>

<p>A potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. Has therapeutic applications in non-metastatic, castration-resistant prostate cancer.</p>

<p>Mineralocorticoid (aldosterone) receptor antagonist</p>

<p>Glucocorticoid receptor agonist; anti-inflammatory</p>

<p>Potent inverse agonist of peroxisome proliferator-activated receptor PPARβ and PPARδ with IC50 value of 27 nM. In mouse myoblasts, DG 172 enhanced recruitment of transcriptional corepressor and down-regulated transcription of PPARβ/δ target gene Angptl4. DG 172 also possess a PPARβ/δ-independent activity on bone marrow cells and promotes dendritic cell differentiation.</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.</p>

Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.

<p>Pan-EGFR inhibitor (HER1, HER2 and HER4); antineoplastic</p>

<p>Agonist of estrogen-related receptors ERRβ and ERRγ. In primary mouse myotubes, GSK 4716 activated ERRβ/γ transcriptional activity and increased expression of mitochondrial genes.</p>

<p>Dual agonist of PPARα and PPARδ receptors</p>

<p>Progesterone receptor antagonist; contraceptive agent</p>

<p>Estrogen receptor degrader; therapeutic use in breast cancer</p>

<p>Endogenous non-toxic agonist of the aryl hydrocarbon receptor (AhR) with immunosuppressive activity. The compound also inhibits the nuclear translocation of Smad2/3/4 leading to aberrant Transforming Growth Factor-β1 (TGFβ1) signaling. It inhibits myofibroblast differentiation and is a potential anti-scarring agent.</p>

<p>PPARα transcription factor agonist</p>

<p>Inhibits EZH2 methyltransferase; antineoplastic</p>

<p>Synthetic estradiol derivative</p>

<p>CYP17 lyase inhibitor; androgen receptor antagonist</p>

<p>Rho/MRTF/SRF mediated gene transcription inhibitor</p>

Canrenone is a steroidal antimineralcorticoid that is used as a diuretic. It has been shown to reduce blood pressure and increase urine volume. Also, this drug has shown to be effective in treating hirsutism in women.

<p>Tretinoin is a type of retinoic acid that can be used for the treatment of acne. It is a chemical inhibitor that binds to nuclear receptors and leads to an increase in apoptosis. This type of retinoic acid helps with cell detachment and increases shedding thus increasing cell turnover. Tretinoin has been shown to have antibacterial efficacy against Staphylococcus aureus, as well as synergistic effects when combined with other agents, such as cyclic lipopeptide antibiotics and quinolones. Additionally, Tretinoin is used in the research and treatment for promyelocytic leukaemia.</p>

<p>PPARγ antagonist</p>

<p>Tamoxifen is used as an antineoplastic agent in the treatment of breast cancer. Tamoxifen has been shown to be a competitive antagonist at the estrogen receptor, preventing estrogen from binding and activating it. <br>Tamoxifen is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Androgen receptor antagonist</p>

<p>Flutamide is an antiandrogen drug that is used in the treatment of metastatic prostate carcinoma. This drug is a non-steroidal drug that works by blocking the binding of androgens to their receptors in the body, which helps to inhibit the growth and spread of prostate cancer cells.</p>

<p>Glucocorticoid; anti-inflammatory; anti-asthmatic agent</p>

<p>Tazarotene is an acetylenic retinoid that is used for the treatment of wrinkles, pigmentation of the skin and acne. Although, the mechanism of action for this drug is not yet fully understood, it is thought to bind to all three members of the retinoic acid receptor family. Studies have shown that this drug is associated with increased collagen production.</p>

<p>Budesonide is a glucocorticoid receptor drug that is used to treat inflammatory diseases of the lungs such as COPD, Crohn’s disease and asthma. This drug promotes anti-inflammatory genes such as interleukin-10. Budesonide aims to reduce inflammation in patients suffering from respiratory disease.</p>

<p>Nilutamide is an antineoplastic agent that is used to treat prostate cancer. This drug is an androgen receptor antagonist and binds with androgen receptors thus blocking its action and resulting in growth arrest.</p>

<p>Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.</p>

<p>Used to treat psoriasis; teratogenic</p>

<p>As a synthetic trifluorinated glucocorticoid receptor agonist, Fluticasone exhibits anti-inflammatory properties. When binding to and activating glucocorticoid receptors, Fluticasone initiates the activation of lipocortin which inhibits cytosolic phospholipase A2. Consequently, the cascade of inflammatory mediator synthesis reactions are inactivated and the production of inflammatory cells namely mast cells, dendritic cells, macrophages and eosinophils and the cytokines that they produce are greatly reduced.It is this anti-inflammatory role which has enabled Fluticasone to successfully treat conditions such as asthma, emphysema, allergic rhinitis and atopic dermatitis. It has also been seen to increase anti-inflammatory effects of annexoin-1 and mitogen-activated kinase phosphatase-1; reduce mucus gland secretions and increase the number of beta-2 receptors on smooth muscles of the airways.<br>Fluticasone is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.</p>

Antagonist of androgen receptor

<p>Glucocorticoid receptor agonist; anti-inflammatory; immunosuppressant</p>

<p>Modulator of RBP protein; activator of sphingomyelinase; pro-apoptotic</p>

<p>Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia.</p>

<p>Corticosteroid; anti-inflammatory; treats dermatological conditions</p>

<p>Acitretin is a synthetic retinoid that can be used to treat skin conditions such as acne, psoriasis, and eosinophilic fasciitis. It has been shown to be an active inhibitor of squamous cell carcinoma in the laboratory. Acitretin works by inhibiting the excessive cell growth and keratinisation seen in psoriasis therefore reducing the thickening of the skin, plaque formation and scaling.</p>

<p>Calcitriol is a steroid hormone, vitamin D metabolite and agonist of vitamin D receptor (VDR), also known as calcitriol receptor. It regulates absorption of calcium from intestine, resorption of bone calcium and calcium excretion via kidneys. This compound also controls cell cycle, promotes cell differentiation, triggers apoptosis and acts as anti-inflammatory factor within the tumor microenvironment. It has anti-proliferative effects in malignant epithelial cells and in tumour-derived endothelial cells (TDEC). Also, it is a potent inhibitor of retinal neoangiogenesis in vitro.</p>

<p>Androgen receptor antagonist; therapy for endometriosis</p>

Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.

Retinoic acid receptor alpha agonist; antineoplastic

Raloxifene is an estrogen receptor modulator that is used in the prevention and treatment of osteoporosis and breast cancer in postmenopausal women. This drug acts as an estrogen agonist and antagonist. Also, Raloxifene has antiproliferative effects.

<p>Inhibitor of HIF1-α transcription factor and repressor of HIF1-α-regulated genes in adult and embryonic stem cell models as well as in tumoral cell lines. FM19G11 inhibits the expression of undifferentiating factors Oct4, Sox2, Nanog, and Tgf-α at transcriptional and protein level. FM 19G11 affects also epigenetic events by reducing histone acetylation and leading to repression of p300, a HIF-transcription activation co-factor.</p>

<p>Inhibits binding of endogenous ligands to peroxisome proliferator-activated receptor gamma (PPARγ), blocking its activation and transcription. Unlike orthosteric antagonists GW 9662 and T 0070907, SR 16832 blocks both allosteric and orthosteric activation of PPARγ.</p>

<p>Androgen receptor antagonist; anti-cancer agent</p>

<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>

PODXL Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q9WTQ2.

TREX1 Protein, Mouse, Recombinant (His & Myc) is expressed in E.

Tsukushi Protein, Mouse, Recombinant (His & Myc) is expressed in E.

Glycodelin Protein, Human, Recombinant (His) is expressed in E.

Involved in endochondral bone formation as negative regulator of bone mineralization.

FTO Protein, Human, Recombinant (His & Myc) is expressed in E. coli.

Frataxin/FXN Protein, Human, Recombinant (His & Myc) is expressed in E.

Coordinates the incorporation of A36 into intracellular enveloped virion (IEV) membranes and, subsequently, the production of actin tails.

May be a survival factor for hippocampal and mesencephalic neurons.

Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.

Thrombin-like snake venom serine protease.

ENR Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E.

SLC25A6 Protein, Human, Recombinant (His & KSI) is expressed in E.

Rotavirus A (strain St.

HRH1 Protein, Human, Recombinant (His) is expressed in E. coli.

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.

This is the major myelin protein from the central nervous system.

Viral mimic of eIF-2-alpha that acts as a pseudosubstrate for EIF2AK2/PKR kinase.

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition.

RAB44 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli.

Inhibits mammalian elastases.

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Constant region of T cell receptor (TR) beta chain.

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.

Removes the N-terminal methionine from nascent proteins.