Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
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GNE 6776
CAS :Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formule :C20H20N4O2Degré de pureté :Min. 95%Masse moléculaire :348.4 g/molPimecrolimus
CAS :Immune suppressant; prevents pro-inflammatory cytokine releaseFormule :C43H68ClNO11Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :810.45 g/molIdelalisib
CAS :Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formule :C22H18FN7ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :415.42 g/molBKM 120
CAS :Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formule :C18H21O2N6F3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :410.39 g/molSRT1720 hydrochloride
CAS :SIRT1 activatorFormule :C25H23N7OS·xHClDegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :469.56 g/molPimasertib
CAS :A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formule :C15H15FIN3O3Degré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :431.2 g/molJNJ 10198409
CAS :Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formule :C18H16FN3O2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :325.34 g/molA 939572
CAS :Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Formule :C20H22ClN3O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :387.86 g/molKU-0063794
CAS :Inhibits mTORC1 and mTORC2 serine/threonine kinasesFormule :C25H31N5O4Degré de pureté :Min. 95%Couleur et forme :White To Beige To Yellow SolidMasse moléculaire :465.54 g/mol5-Fluoro-1-(tetrahydro-2-furyl)uracil
CAS :5-Fluoro-1-(tetrahydro-2-furyl)uracil is a chemotherapeutic agent, which is a synthetic derivative of uracil. This compound is developed from modified nucleosides with the aim of enhancing antitumor efficacy. Its mechanism of action involves the inhibition of thymidylate synthase, leading to a disruption in DNA synthesis. By integrating into RNA and DNA, it ultimately impedes tumor cell proliferation due to RNA processing interference and DNA damage.Formule :C8H9FN2O3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :200.17 g/molMK 1775
CAS :Wee1 inhibitor with an IC50 of 5.2 nMFormule :C27H32N8O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :500.6 g/molPeiminine
CAS :Inhibitor of TGF-α, CTGF, ERK1/2, NF-κB and FasL; anti-inflammatoryFormule :C27H43NO3Degré de pureté :Min. 98 Area-%Masse moléculaire :429.64 g/molSGC AAK1 1
CAS :Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Formule :C21H25N5O3SDegré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :427.52 g/molDeracoxib
CAS :Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib classFormule :C17H14F3N3O3SDegré de pureté :Min. 95%Couleur et forme :White To Off-White To Brown SolidMasse moléculaire :397.37 g/molHistone deacetylase inhibitor VIII
CAS :Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.
Formule :C22H30N4O6Degré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :446.21653Hydroxychloroquine sulfate - Bio-X ™
CAS :Hydroxychloroquine is a drug that is used to treat multiple types of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus and discoid lupus. It is a prodrug, which is activated in the liver to hydroxychloroquine. It inhibits the production of inflammatory cytokines and nitric oxide by binding to the toll-like receptor 4 (TLR4) and inhibiting signaling pathways downstream of TLR4 activation. Additionally, Hydroxychloroquine is used to prevent and treat malaria caused by parasitic protozoan from the Plasmodium genus. Furthermore, recent studies revealed that hydroxychloroquine has beneficial effects on COVID-19 patients, as the current evidence shows that hydroxychloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the spike glycoprotein.Formule :C18H28ClN3O5SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :433.95 g/molEN 6
CAS :Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFormule :C19H14F2N4O2Degré de pureté :Min. 95%Couleur et forme :White To Yellow To Beige SolidMasse moléculaire :368.34 g/molNilotinib HCl monohydrate - Bio-X ™
CAS :Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formule :C28H22F3N7O•HCl•H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :583.99 g/molCobicistat
CAS :Cobicistat is an inhibitor of human cytochrome P450 3A enzymes (CYP) with no antiviral activity. Cobicistat is used in the treatment of HIV-1 infection, as an alternative to ritonavir, to increase the half-life of antiviral medications (von Hentig, 2016). Cobicistat acts as a booster by selectively inhibiting the hepatic degradation of the drugs, for example, in the pharmacological regime against HIV-1, which often includes protease inhibitors, such as, darunavir, atazanavir, and lopinavir, or the integrase inhibitor elvitegravir (Deeks, 2014).Formule :C40H53N7O5S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :776.03 g/molNVP-BGJ398
CAS :Inhibits FGFR family of kinases; antineoplastic; anti-angiogenicFormule :C26H31Cl2N7O3Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :560.48 g/mol
