Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
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D 4476 - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
Formule :C23H18N4O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :398.41 g/molGDC 0941
CAS :Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formule :C23H27N7O3S2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :513.64 g/molPKC 412
CAS :Inhibits multiple protein kinases, such as PKC and FLT3Formule :C35H30N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :570.64 g/molTivozanib
CAS :Inhibitor of VEGF receptorsFormule :C22H19ClN4O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :454.86 g/molDabigatran etexilate - Bio-X ™
CAS :Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.
Formule :C34H41N7O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :627.73 g/molTacrolimus monohydrate
CAS :Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormule :C44H69NO12·H2ODegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :822.03 g/molALW-II-41-27 - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C32H32F3N5O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :607.69 g/molApatinib mesylate
CAS :Inhibitor of VEGFR; antineoplasticFormule :C24H23N5O·CH4O3SDegré de pureté :Min. 95%Masse moléculaire :493.58 g/molGSK 626616 - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C18H10Cl2N4OSDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :401.27 g/molTDZD 8 - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C10H10N2O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :222.26 g/mol3-Deazaneplanocin hydrochloride - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C12H14N4O3•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :298.73 g/molPomalidomide
CAS :Produit contrôléPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM.In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies.Formule :C13H11N3O4Degré de pureté :Min. 98 Area-%Couleur et forme :Yellow PowderMasse moléculaire :273.24 g/molLinagliptin - Bio-X ™
CAS :Linagliptin is a dipeptidyl peptidase-4 inhibitor drug that is used to manage hyperglycaemia in patients with type 2 diabetes. This drug works by inhibiting the enzyme dipeptidyl peptidase-4 and allows for the breakdown of GLP-1 and glucose dependent insulinotropic polypeptide. As a result of this, breakdown of glycogen is reduced and release of insulin is increased. Linagliptin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C25H28N8O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :472.54 g/molPX 866
CAS :Potent and irreversible inhibitor of phosphoinositide-3-kinase (PtdIns-3-kinase) with IC50 of 0.1 nM. PX 866 inhibited cell motility and growth of 3D spheroids of glioblastoma, breast, prostate and colon cancer cell lines at low nanomolar concentrations. PX 866 also exhibited anti-tumoral activity in vivo in xenograft models for ovarian and lung cancer.Formule :C29H35NO8Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :525.59 g/molAmlexanox - Bio-X ™
CAS :Amlexanox is an antiallergic and anti-inflammatory drug that has been shown to be effective in treating rhinitis and allergic asthma in clinical studies. It prevents the slow-reacting substance of anaphylaxis (SRS-A) from being released chemically as a mediator and may have antagonistic effects on interleukin-3.Formule :C16H14N2O4Degré de pureté :(%) Min. 99%Couleur et forme :PowderMasse moléculaire :298.29 g/molN-Butyldeoxynojirimycin
CAS :Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.Formule :C10H21NO4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :219.28 g/molSulbactam - Bio-X ™
CAS :Sulbactam is a synthetic antibacterial agent that inhibits bacterial cell wall synthesis. Sulbactam is a potent inhibitor of bacterial DNA-dependent RNA polymerase. The combination of sulbactam and polymyxin B has been shown to have synergistic inhibitory effects on Gram-negative bacteria and is used as an intravenous antibiotic for the treatment of infections caused by Gram-negative bacteria.
Formule :C8H11NO5SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :233.24 g/molMasitinib
CAS :Masitinib is an orally bioavailable inhibitor of c-Kit, PDGFR and FGFR3 tyrosine. It is an antineoplastic which has been studied for applications in a range of human diseases including Alzheimers and cancer and is currently used to treat mast cell tumours in animals. As part of a screening study, Masitinib was shown to be highly effective in blocking SARs-CoV-2 replication.Formule :C28H30N6OSDegré de pureté :Min. 98 Area-%Couleur et forme :Off-White To Gray SolidMasse moléculaire :498.64 g/molEntinostat
CAS :Inhibits histone deacetylase (HDAC)
Formule :C21H20N4O3Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :376.15354Tivozanib - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C22H19ClN4O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :454.86 g/molTeniposide - Bio-X ™
CAS :Teniposide is a cytotoxic drug that is used in the treatment of refractory childhood acute lymphoblastic leukemia. It has antitumour activity. It is a type II topoisomerase inhibitor. This drug inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.Formule :C32H32O13SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :656.65 g/molLorlatinib
CAS :Brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK) and proto-oncogene kinase ROS1. It is a reversible ATP-competitor, interacting with P-loop (L1122, G1123, V1130) and K1150 residue of ALK tyrosine kinase. It has major implications in the treatment of non-small cell lung cancer (NSCLC). The compound is used for resensitization of drug resistant, ALK-mutated cancers to crizotinib chemotherapy and was shown to trigger the regression of EML40ALK-driven brain metastases.Formule :C21H19FN6O2Degré de pureté :Min. 95%Masse moléculaire :406.41 g/molLDN 193189 dihydrochloride
CAS :Inhibitor of ALK1, ALK2, ALK3 and ALK6 kinases and bone morphogenetic protein (BMP) pathway. LDN 1931189 is a dorsomorphin derivative that inhibits BMP-mediated activation of Smad, Akt and p38 signalling. LDN 193189 promotes differentiation of human pluripotent cells into PAX6+ anterior neural ectoderm. In combination with basic fibroblast growth factor (FGF2), LDN 193189 promotes differentiation of mouse pluripotent stem cells into inner ear sensory epithelium.Formule :C25H22N6·2HClDegré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :479.4 g/mol(S,S,S)-Enalapril maleate - Bio-X ™
CAS :Enalapril is a long-acting angiotensin-converting enzyme inhibitor. It is used to treat hypertension and congestive heart failure, as well as chronic cough due to postnasal drip or bronchitis. Enalapril is an active inhibitor of the synthesis of angiotensin II and other vasoconstrictor substances that are involved in the regulation of blood pressure. It binds reversibly to the active site on angiotensin-converting enzyme (ACE) and blocks its activity by forming strong hydrogen bonds with residues on ACE, thereby preventing it from converting angiotensin I into angiotensin II. This leads to a significant reduction in blood pressure.Formule :C24H32N2O9Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :492.52 g/molCabozantinib malate
CAS :Inhibits MET, VEGFR1, VEGFR2; VEGFR3 receptor tyrosine kinases; antineoplasticFormule :C28H24FN3O5·C4H6O5Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :635.6 g/molTrilostane - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
Formule :C20H27NO3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :329.43 g/molOglemilast
CAS :Inhibitor of PDE4 enzymeFormule :C20H13Cl2F2N3O5SDegré de pureté :Min. 95%Masse moléculaire :516.3 g/molVaborbactam
CAS :Inhibitor of β-lactamase enzymes
Formule :C12H16BNO5SDegré de pureté :Min. 95%Couleur et forme :Yellow PowderMasse moléculaire :297.14 g/molFasudil hydrochloride
CAS :Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis.Formule :C14H17N3O2S•HClDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :327.83 g/molNicotinamide - Bio-X ™
CAS :Nicotinamide is a form of vitamin B that is found in food and it used to treat many conditions such as pellagra and acne. It replenishes cellular energy and has anti-inflammatory effects. Nicotinamide is an inhibitor of the enzyme SIRT1 in vitro but can be a stimulator in cells.Formule :C6H6N2ODegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :122.12 g/mol4-Methylpyrazole
CAS :4-Methylpyrazole is a competitive inhibitor of alcohol dehydrogenase, which can be used to treat methanol and ethylene glycol poisoning. It is also used to inhibit the metabolism of ethanol by blocking the conversion of ethanol to acetaldehyde. 4-Methylpyrazole is metabolized into 4-methylpyridinium ion (4MP) by alcohol dehydrogenase, which prevents the conversion of acetaldehyde to acetic acid. This results in an increase in blood levels of acetaldehyde and a decrease in blood levels of acetic acid, leading to an accumulation of toxic metabolites such as formic acid. In addition, 4-methylpyrazole inhibits the enzyme glycol dehydrogenase that breaks down glycols into their harmless components. This leads to an accumulation of toxic intermediate products that are converted back into glycols.Formule :C4H6N2Degré de pureté :Min. 95%Couleur et forme :Colorless PowderMasse moléculaire :82.1 g/molCP 724714
CAS :Inhibitor of ErbB2 (IC50 = 3 nM) and EGFR kinase (IC50 = 6.4 nM) with anti-proliferative effects. It inhibits ErbB2 receptor autophosphorylation and induces G1 cell cycle block. The CP 724714 treatment induces reduction of downstream ErbB2 receptor tyrosine kinase signalling, tumor cell apoptosis, release of caspase 3 and regression of tumors in in vivo and in vitro models.Formule :C27H27N5O3Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :469.54 g/molBrensocatib
CAS :Rensocatib is a reversible inhibitor of DPP-1, also known as cathepsin C, which is a peptidase involved in the activation of neutrophil, an elastase-like serine protease in lung tissue. Brensocatib is an oral drug used to treat infections of the airways (lungs) that are characterised by a permanent enlargement and presenting symptoms such as, coughing and greater mucus production (bronchiectasis). Alternative names of brensocatib are INS-1007 and AZD7986.
Formule :C23H24N4O4Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :420.46 g/molRomidepsin - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C24H36N4O6S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :540.7 g/mol3-Deazaneplanocin hydrochloride
CAS :Inhibitor of S-adenosylhomocysteine hydrolase that disrupts histone methylation by EZH2. Anti-proliferative in some breast cancer and invasive prostate cancer cell lines. One of four key molecules required for inducing chemical reprogramming of somatic cells into induced pluripotent stem cells (iPSC).Formule :C12H14N4O3·ClHDegré de pureté :Min. 98 Area-%Couleur et forme :Beige PowderMasse moléculaire :298.73 g/molSB 239063 - Bio-X ™
CAS :This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C20H21FN4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :368.4 g/molMoclobemide - Bio-X ™
CAS :Produit contrôléMoclobemide is a monoamine oxidase inhibitor that is used to treat major depressive disorder and dipolar disorder. This drug’s mechanism of action involves the reversible inhibition of the enzyme MAO-A. The inhibition of this enzyme results in a decreased metabolism and destruction of neurotransmitters thus relieving the symptoms of depression and bipolar disorder.Formule :C13H17ClN2O2Degré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :268.74 g/molLY 2334737
CAS :Orally available prodrug of gemcitabineFormule :C17H25F2N3O5Degré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :389.39 g/molDoxorubicin hydrochloride - Bio-X ™
CAS :Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.Formule :C27H29NO11•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :579.98 g/molFirocoxib
CAS :COX-2 enzyme inhibitor; anti-inflammatoryFormule :C17H20O5SDegré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :336.40 g/mol3-Deazaneplanocin hydrochloride - Technical
CAS :Inhibitor of S-adenosylhomocysteine hydrolase that disrupts histone methylation by EZH2. Anti-proliferative in some breast cancer and invasive prostate cancer cell lines. One of four key molecules required for inducing chemical reprogramming of somatic cells into induced pluripotent stem cells (iPSC).
Formule :C12H14N4O3·ClHDegré de pureté :Min. 70 Area-%Couleur et forme :PowderMasse moléculaire :298.73 g/molAzathioprine - Bio-X ™
CAS :Azathioprine belongs to the group of immunosuppressant drugs that suppress the immune system by inhibiting the production of white blood cells (leukocytes). It is used to treat inflammatory diseases, such as rheumatoid arthritis, lupus, and Crohn's disease. Azathioprine is metabolized in the liver. Additionally, this drug inhibits DNA synthesis by binding to nuclear DNA, preventing RNA transcription and protein synthesis in susceptible cells.Formule :C9H7N7O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :277.26 g/molImatinib mesylate - Bio-X ™
CAS :Imatinib is a tyrosine kinase inhibitor drug that is used for the treatment of various leukaemias, gastrointestinal stromal tumours and myeloproliferative disease. This drug inhibits the BCR-ABL tyrosine kinase and thus prevents the downstream phosphorylation of target proteins. This drug also inhibits PDGF, SCF and c-kit.Formule :C29H31N7O·CH4O3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :589.71 g/molN-ω-Propyl-L-arginine - Bio-X ™
CAS :N-ω-Propyl-L-arginine is a selective inhibitor of neuronal nitric oxide synthase (nNOS). This enzyme is involved in the production of nitric oxide, which plays important roles in various physiological and pathological processes in the body. N-ω-Propyl-L-arginine selectively inhibits nNOS, preventing the conversion of L-arginine to nitric oxide. This makes it a useful tool for studying the role of nNOS in various Life Sciences fields, such as neuroscience and cardiovascular research. It can also be used as an enzyme modulator or ligand in drug discovery studies targeting nNOS. N-ω-Propyl-L-arginine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C9H20N4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :216.28 g/molGSK 1278863
CAS :Produit contrôléInhibitor of HIF-prolyl hydroxylase isozymes PHD1, PHD2 and PHD3 with Ki in nanomolar range. The compound mimics the binding of N-oxalylglycine, chelates catalytic iron and prevents substrate entry into catalytic site. Inhibition of PHD enzymes leads to stabilization of hypoxia-induced factors HIF1α and HIF2α, followed by the production of erythropoietin (EPO).Formule :C19H27N3O6Degré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :393.43 g/molPentoxifylline - Bio-X ™
CAS :Produit contrôléPentoxifylline is a methylxanthine derivative that is used to treat intermittent claudication that is caused by chronic occlusive arterial disease of the limbs. This drug also has antioxidant and anti-inflammatory properties. Pentoxifylline is a phosphodiesterase inhibitor aiding to increase levels of cAMP.Formule :C13H18N4O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :278.31 g/molGSK 2126458
CAS :PI3K enzyme inhibitor; antineoplastic
Degré de pureté :Min. 98 Area-%Couleur et forme :PowderRibociclib HCl
CAS :Inhibitor of CDK4/6 serine/threonine kinases; antineoplasticFormule :C23H30N8O·HClDegré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :471 g/molGSK 360A
CAS :Inhibitor of prolyl 4-hydroxylase PHDFormule :C17H17FN2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :348.33 g/molVX 680
CAS :Aurora kinase inhibitor; antineoplasticFormule :C23H28N8OSDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :464.59 g/mol
