KN-62

CAS : 127191-97-3

Ref. 02-J62444

Informations sur le produit

• Nom: KN-62
• Synonymes: (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)Methylamino]- 3-Oxo-3-[4-Phenyl-1-Piperazinyl]Propyl)Phenyl Ester, 1-[N,O-Bis-(5-Isoquinolinesulfonyl)-N-Methyl-L-Tyrosyl]-4-Phenylpiperazine, 4-((2s)-2-((5-Isoquinolinylsulfonyl)Methylamino)-3-Oxo-3-(4-Phenyl-1-Piperazinyl)Propyl)Phenylisoquinolinesulfonicacid, 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl 5-isoquinolinesulfonate, 4-[(2S)-2-[(isoquinolin-5-ylsulfonyl)(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl isoquinoline-5-sulfonate, 4-{2-[(Isoquinolin-5-Ylsulfonyl)(Methyl)Amino]-3-Oxo-3-(4-Phenylpiperazin-1-Yl)Propyl}Phenyl Isoquinoline-5-Sulfonate, 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 5-Isoquinolinesulfonic acid, 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, (S)-, Kn-62

Description

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

• Marque: Alfa Aesar By Thermo Fisher Scientific

Propriétés chimiques

• Masse moléculaire: 721.84
• Formule: C₃₈H₃₅N₅O₆S₂
• Couleur/Forme: Powder