4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile

CAS : 675126-26-8

Ref. 3D-ACB12626

Informations sur le produit

• Nom: 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile
• Synonymes: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile, 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile, 2-Nitro-4-methoxy-5-[3-(morpholin-4-yl)]propoxybenzonitrile, 4-Methoxy-5-[3-(4-morpholinyl)propoxy]-2-nitrobenzonitrile, Gefitinib Intermediate 1

Description

4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile is a synthetic intermediate for the synthesis of gefitinib, an anticancer medicine that is used to treat non-small cell lung cancer. The compound reacts with chloro-, 3-chloro-4-fluoroaniline and benzamide in the presence of phosphoric acid to produce the desired product. The reaction proceeds through a transfer hydrogenation mechanism, which is catalyzed by palladium chloride. This process produces 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile at high yield and with excellent purity. It has been shown that the reaction intermediates can be salified with hydrochloric acid or hydrobromic acid to form a stable salt.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 321.33 g/mol
• Formule: C₁₅H₁₉N₃O₅
• Degré de pureté: Min. 95%