(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

CAS : 175556-12-4

Ref. 3D-AHA55612

Informations sur le produit

• Nom: (R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
• CAS: 175556-12-4

Description

(R)-4-(tert-Butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide is a non-peptide antagonist of endothelin A (ET A ) and endothelin B (ET B ). It has been shown to have a high selectivity for ET A over ET B , with potency at concentrations of 1 nM for ET A and 100 nM for ET B . This compound has been shown to inhibit the release of vasoconstrictive endothelin from cultured human endothelial cells. The inhibition is concentration dependent, with shifts in the concentration-response curves being observed as low as 10 μM. The inhibition of release was characterised by clarifying the mechanism involved.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 609.7 g/mol
• Formule: C₃₁H₃₅N₃O₈S
• Degré de pureté: Min. 95%