KU-60019

CAS : 925701-49-1

Ref. 3D-AMB70149

Informations sur le produit

• Nom: KU-60019
• Marque: Biosynth
• Description: KU-60019 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. KU-60019 blocks the activation of EGFR and other signaling pathways, which may be involved in the pathogenesis of autoimmune diseases, cancer and metabolic disorders. KU-60019 inhibits cellular proliferation by inhibiting tyrosine phosphorylation in the EGFR pathway. In addition, KU-60019 also inhibits DNA synthesis and cell cycle progression by targeting other intracellular targets such as cyclin D1, CDK4, CDK6 and p27. The chemical structure of KU-60019 is similar to that of imatinib mesylate, an inhibitor for chronic myeloid leukemia that has been approved by the FDA for treatment. However, unlike imatinib mesylate, KU-60019 does not inhibit protein kinase C or Raf kinases. Further investigations are needed to determine the mechanism

Propriétés chimiques

• Masse moléculaire: 547.67 g/mol
• Formule: C₃₀H₃₃N₃O₅S
• Degré de pureté: Min. 95%