Yellow Fever Virus NS1 Antigen Mouse Monoclonal Antibody

Ref. 3D-AZ1264

Informations sur le produit

• Nom: Yellow Fever Virus NS1 Antigen Mouse Monoclonal Antibody
• Marque: Biosynth
• Description: A mouse monoclonal antibody (Mab) purified by ion exchange chromatography, presented as a liquid in 0.015M potassium phosphate, 0.85% NaCl, pH 7.2, is a cell-culture derived lysate from strain 17D. Immunoglobulin subclasses IgG1k and IgG2a are available and are potentially suitable for ELISA, rapid lateral flow applications and other immunoassay formats for detection of the Yellow Fever NS1 protein.The occurrence of the viral infection Yellow Fever is largely in Africa and South America where Mosquitoes infected with this Flaviviridae family virus bite humans and transmit the virus. Although symptoms can be mild, severe cases can lead to diseases such as hepatitis and renal failure. The NS1 glycoprotein, complementary to the mouse mab to the Yellow Fever Virus (YFV), is one of 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) encoded for by the single stranded RNA of the YFV. Interestingly NS1 can be found within the viral cell as a monomer, on the cell surface as a hydrophobic dimer and as a hexameric species when secreted. NS1 plays a role in virus assembly and it's 12 invariant cysteine residues allow it to function within RNA replication and hence contribute to reducing the host's immune response. Monoclonal antibodies complementary to the NS1 protein bind and inhibit activity and hence can be used in vaccine to offer immunity against YF.

Propriétés chimiques

• Degré de pureté: >90% By Sds-Page.