C-Reactive Protein Mouse Monoclonal Antibody

Ref. 3D-AZ1280

Informations sur le produit

• Nom: C-Reactive Protein Mouse Monoclonal Antibody
• Marque: Biosynth
• Description: Complementary to the human C-Reactive Protein (CRP), this mouse monoclonal antibody is of the immunoglobulin class IgG and has been purified by protein A chromatography and presented as a liquid in PBBS, pH 7.4.CRP is an acute-phase inflammatory, pentameric plasma protein. Awarded its name after being first discovered reacting with the capsular (C)-polysaccharide of the Pneumococcus infection, the CRP has since been found to activate the classical complement pathway of innate immunity. Dependent on the presence of calcium ions on its ligand-binding face, CRP specifically stimulates C1q when binding to phosphocholine and other polysaccharides located on microorganisms. Expression of CRP is increased (primarily in the hepatocytes) when inflammatory cytokines such as interleukin-6 are elevated during infection and some conditions such as rheumatoid arthritis and cardiovascular diseases.Two clones of this product are available clone 2102028 and clone 2002018 . Clone 2102028 is recommended for capture whereas clone 2002018 could be applied as a detection antibody in immunoassay development and clinically to monitor inflammation in diseases such as sepsis and autoimmune diseases.