BIO

CAS : 667463-62-9

Ref. 3D-BB162775

Informations sur le produit

• Nom: BIO
• Synonymes: (2'Z,3'E)-6-Bromoindirubin-3'-oxime, (3Z)-6-Bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, (2′Z,3′E)-6-Bromoindirubin-3′-oxime, 2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-, GSK 3 IX, GSK 3 Inhibitor IX

Description

Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 356.17 g/mol
• Formule: C₁₆H₁₀BrN₃O₂
• Degré de pureté: Min. 95%
• Couleur/Forme: Red To Dark Red Solid
• InChI: InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
• Code InChI: InChIKey=SAQUSDSPQYQNBG-UHFFFAOYSA-N
• SMILES: O=Nc1c(-c2c(O)[nH]c3cc(Br)ccc23)[nH]c2ccccc12