WM 1119

CAS : 2055397-28-7

Ref. 3D-BW166843

Informations sur le produit

• Nom: WM 1119
• CAS: 2055397-28-7

Description

Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 389.38 g/mol
• Formule: C₁₈H₁₃F₂N₃O₃S
• Degré de pureté: Min. 95%
• Couleur/Forme: White/Off-White Solid
• InChI: InChI=1S/C18H13F2N3O3S/c19-14-10-12(16-6-3-4-8-21-16)9-13(11-14)18(24)22-23-27(25,26)17-7-2-1-5-15(17)20/h1-11,23H,(H,22,24)
• Code InChI: InChIKey=QLXULUNLCRKWRD-UHFFFAOYSA-N
• SMILES: O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccccn2)c1