2-Amino-4-phenylthiazole hydrobromide monohydrate
CAS : 52253-69-7
Ref. 3D-CCA25369
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Informations sur le produit
Nom :
2-Amino-4-phenylthiazole hydrobromide monohydrate
Synonymes :
- 4-Phenylthiazol-2-Ylamine Hydrobromide Monohydrate
- 4-Phenyl-1,3-thiazol-2-amine
- 4-Phenyl-1,3-Thiazol-2-Amine Hydrobromide Hydrate
Description :
2-Amino-4-phenylthiazole hydrobromide monohydrate (2APT) is an inhibitor of histone deacetylase. It was synthesized by reacting 2-amino-4-phenylthiazole with hydrobromic acid, and the resulting salt was obtained as a white solid. The structure of 2APT has been determined by X-ray crystallography. The compound is a hydrogen bond donor and a strong hydrophobic ligand, which may be responsible for its binding to the active site of HATs.
2APT inhibits the activity of HATs by forming a covalent bond with the catalytic cysteine residue in the active site. This inhibition leads to decreased acetylation of histones, which results in changes in gene expression and ultimately cell growth arrest or apoptosis.
Avis:
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Marque:
Biosynth
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
275.17 g/mol
Formule :
C9H8N2S·HBr·H2O
Degré de pureté :
Min. 95%
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