PAR-1 agonist/ TRAP6

CAS : 197794-83-5

Ref. 3D-CRB1000217

Informations sur le produit

• Nom: PAR-1 agonist/ TRAP6
• Synonymes: H-TFLLR-NH2PAR1 agonist, H-Thr-Phe-Leu-Leu-Arg-Nh2, Thr-Phe-Leu-Leu-Arg-Nh2, Thrombin Receptor (Par-1), Hybride Human-Xenope, Tfllr-Amide, (Thr1)-TRAP-5 amide

Description

Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-1 agonist peptide represents the sequence of the 'tethered ligand' and is therefore capable of activating the receptor independently of N-terminal proteolysis. TFLLR-NH2 is more selective to PAR-1 than the PAR-1 agonist SFLLRN-NH2.Activation of PAR-1 induces platelet aggregation and IL-6 release from monocytes and T cells, as well as several other cellular pathways including those involved in allergic inflammation, neurogenic inflammation and the potentiation of NMDA receptor activity in the hippocampus.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 647.8 g/mol
• Formule: C₃₁H₅₃N₉O₆
• Degré de pureté: Min. 95%