HLA-A*02:01 MAGE-A1 (278-286)

Ref. 3D-CRB1001109

Informations sur le produit

• Nom: HLA-A*02:01 MAGE-A1 (278-286)
• Synonymes: H-KVLEYVIKV-OH
• Marque: Biosynth
• Description: HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA). HLA-A is a human MHC class I cell surface receptor and is involved in presenting short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. Melanoma-associated antigen 1 (MAGE-A1) is part of a well-characterized group of cancer/testis antigens (CTA) that are encoded as a separate cluster on the X chromosome. MAGE-I antigens are mainly expressed in highly proliferating cells, such as cancer cells and therefore may be ideal targets for cancer immunotherapy. Expression of MAGEs has been reported several types of cancer including: lung- breast- thyroid- colon- stomach- liver and bladder where MAGE-A is considered to be a poor prognostic factor.This peptide corresponds to part of the MAGE-A1 sequence which is presented on the MHC class I antigen HLA-A*02.

Propriétés chimiques

• Masse moléculaire: 1,089.7 g/mol