AD01

Ref. 3D-CRB1001113

Informations sur le produit

• Nom: AD01
• Synonymes: H-IRQQPRDPPTETLELEVSPDPAS-OHIRQQPRDPPTETLELEVSPDPAS-acidH-Ile-Arg-Gln-Gln-Pro-Arg-Asp-Pro-Pro-Thr-Glu-Thr-Leu-Glu-Leu-Glu-Val-Ser- Pro-Asp-Pro-Ala-Ser-OH

Description

AD01 is a derivative of the FK506 binding protein-like (FKBPL), and exerts potent anti-angiogenic activity in vitro and in vivo to control tumour growth. Recent studies have shown that AD-01 inhibits Rac-1 activity, and up-regulates RhoA and the actin binding proteins, profilin and vinculin. In this way, the anti-angiogenic proteins, FKBPL, and AD-01, offer a promising and alternative approach for targeting both CD44 positive tumours and vasculature networks. Recent clinical studies have shown that AD01 and other FKBPL-based peptides may offer an alternative for targeting treatment-resistant breast cancer stem cells.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 2,574.3 g/mol