TAT-AKAP79 (326-336) scrambled

Ref. 3D-CRB1001278

Informations sur le produit

• Nom: TAT-AKAP79 (326-336) scrambled
• Synonymes: H-YGRKKRRQRRRKEMRESKESKS-OHYGRKKRRQRRRKEMRESKESKS-acidH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Glu-Met-Arg-Glu-Ser-Lys-Gl u-Ser-Lys-Ser-OH

Description

The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons and the neurotransmitter anandamide. -The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting domain of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain. This product was shown in vivo to have no effect on TRPV1 algesia and thus is a vital control for research work. This product is a vital tool for research into suitable TRPV1 antagonists.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 2,878.6 g/mol