TAT-AKAP79 (326-336) scrambled amide

Ref. 3D-CRB1001280

Informations sur le produit

• Nom: TAT-AKAP79 (326-336) scrambled amide
• Synonymes: H-YGRKKRRQRRRKEMRESKESKS-NH2YGRKKRRQRRRKEMRESKESKS-amideH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Glu-Met-Arg-Glu-Ser-Lys- Glu-Ser-Lys-Ser-NH2

Description

The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons and the neurotransmitter anandamide.- The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting residues of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain at the N-terminus. The scrambled peptide was shown in vivo to have no effect on TRPV1 algesia and thus is a vital control for research work. This product is a vital tool for research into suitable TRPV1 antagonists. The scrambled-TAT peptide is available for purchase in both an acid and amide form, this is the C-terminal amide form.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 2,877.6 g/mol