AF12198

Ref. 3D-CRB1001289

Informations sur le produit

• Nom: AF12198
• Synonymes: Ac-FEWTPGWYQJYALPL-NH2, J is L-azetidine-2-carboxylic acidAc-FEWTPGWYQJYALPL-amideAc-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-J-Tyr-Ala -Leu-Pro-Leu-NH2CS1IL-1raAc-FEWTPGWYQXYALPL-amide

Description

AF12198 is a selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1) and thus blocks IL-1β signalling. AF12198 can inhibit IL-1-induced IL-8 production by human dermal fibroblasts and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells. AF12198 also blocks IL-1 induction of IL-6 and down regulates IL-6 induction in monkeys. AF12198 does not bind the human type II IL-1 receptor, or the murine type I IL-1 receptor.IL-1 influences a wide range of immune and inflammatory responses. Sustained expression of even low levels of IL-1 can be harmful in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 1,895.9 g/mol