Angiotensin 1-7 dual heavy

Ref. 3D-CRB1300303

Informations sur le produit

• Nom: Angiotensin 1-7 dual heavy
• Synonymes: DR-[U-13C5,15N-Val]-Y-[U-13C6,15N-Ile]-HP-acidH-Asp-Arg-[U-13C5,15N-Val]-Tyr-[U-13C6,15N-Ile]-His-Pro-OH

Description

Angiotensin 1-7 (Ang-(1-7)) is a component of the renin angiotensin system RAS. Ang-(1-7) is produced by angiotensin-converting enzyme 2 (ACE2), from the angiotensin II (Ang-II) peptide, as well as by prolylendopeptidase (PEP) and neutral endopeptidase (NEP) which produce Ang-(1-7) directly from angiotensin I (Ang-I).Ang-(1-7) broadly opposes Ang-II actions. Ang-(1-7) has vasodilatory and anti-oxidative effects, and exerts protective actions in hypertension, diabetes, and other cardiovascular disorders, Ang-(1-7) therefore represents a promising therapeutic target for cardiovascular and metabolic diseases. Ang-(1-7) exerts its actions via its G-protein-coupled receptor, Mas. This novel arm of the RAS has effects that counterbalance those mediated by the classical ACE/Ang-II pathway.The valine residue at position 3 and the isoleucine residue at position 5 of this peptide are isotopically labelled with carbon-13 (11) and nitrogen-15 (2), giving this peptide a mass increase of 13 compared to the unlabelled peptide.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 911.5 g/mol
• Degré de pureté: Min. 95%
• Couleur/Forme: Powder