Anti-phosphorylated NR2A (pS1232) antibo - 1mg/mL

Ref. 3D-CRB2005001

Informations sur le produit

• Nom: Anti-phosphorylated NR2A (pS1232) antibo - 1mg/mL

Description

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. In addition NMDARs have also been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

NMDARs are phosphorylated by both serine/threonine and tyrosine kinases. Cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at the serine residue at position 1232. Phosphorylation of NR2A at Ser1232 (p-NR2AS1232) by Cdk5/p35 may contribute to neuronal cell death.

The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

Data: Western blot analysis of rat brain preparation.
Lane 1: Rat brain preparation (20µg).
Secondary: Goat anti-rabbit IgG conjugated to HRP 1:2000.

• Marque: Biosynth