Anti-mGluR1 antibody - 1mg/mL

Ref. 3D-CRB2005006

Informations sur le produit

• Nom: Anti-mGluR1 antibody - 1mg/mL

Description

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, homer.

mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber-Purkinje cell synapses critical for cerebellar motor learning.

Data: Dako FLEX Plus.Immunohistochemistry analysis of human adult brain formalin-fixed paraffin-embedded (FFPE) tissue.
Immunoreactivity detected in the cytoplasm and membrane of neuronal cells in the human cerebral cortex
Detection: Anti-Rabbit Secondary

• Marque: Biosynth