Anti-Cyclin D1 antibody

Ref. 3D-CRB2005024

Informations sur le produit

• Nom: Anti-Cyclin D1 antibody

Description

Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression.

Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types.

Data: Newcastle University Western blot analysis of whole cell extract of human prostate adenocarcinoma (PC-3) and human osteocarcinoma (U-2 OS) (12µg).
Lane 1: Human PC-3 protein (12µg).
Lane 2: Human U-2 OS protein (12µg).

• Marque: Biosynth