Anti-RAMP3 antibody - 0.2mg/mL

Ref. 3D-CRB2005161

Informations sur le produit

• Nom: Anti-RAMP3 antibody - 0.2mg/mL

Description

Anti-RAMP3 antibody corresponds to a region within the human RAMP3 C-terminal protein sequence. RAMP3 is a receptor activity-modifying protein and can interact with G-protein coupled receptors (GPCRs) to alter their function. When in complex with the calcitonin like-receptor (CLR), RAMP chaperones CLR to the surface of the cell where it forms an adrenomedullin2 (AM2) receptor specific for the peptide hormone adrenomedullin. Conversely the calcitonin receptor (CTR) can translocate to the cell surface without RAMP, however RAMP requires CTR to reach the cell surface. It is evident through the use of screening that RAMP requires an interaction with a molecule to translocate to the cell surface. RAMP3 contains a single transmembrane spanning domain, an extracellular N-terminal domain and multiple glycosylation sites. Within the C-terminus two basic residues serve as an endoplasmic retrieval signal. In contrast with Human RAMP1 and 2, Human RAMP3 contains a type-1 PDZ1 recognition site which interacts with Na+/H+ exchange regulatory factor (NHERF) or N-ethylmaleimide-sensitive factor (NSF). This interaction effects GPCR function through altering receptor internalization and recycling.
0.22 mg/ml. For use in ELISA (1:1000). Reacts with human.

• Marque: Biosynth