Anti-phospho-FoxO1 (pS218) antibody - 0.5mg/mL

Ref. 3D-CRB2005226

Informations sur le produit

• Nom: Anti-phospho-FoxO1 (pS218) antibody - 0.5mg/mL

Description

Forkhead box O1 (FoxO1) is a transcriptional regulator of cell growth and proliferation controlled by a receptor tyrosine kinase signalling pathway (the vascular endothelial growth factor A (VEGF-A)/phosphatidylinositol-3-OH kinase (PI3K)/protein kinase B (PKB/Akt) pathway). FoxO1 is phosphorylated in the DNA binding domain at serine 218 by aPKCλ. FoxO1 Ser218 phosphorylation and aPKC expression correlate with poor patient prognosis in various cancers. VEGF/PI3K/Akt signalling results in FoxO1 cytoplasmic localisation and its inactivation. Cytoplasmically localised FoxO1 is associated with cellular myelocytomatosis (c-Myc) expression and endothelial cell (EC) proliferation. Abnormal atypical protein kinase C (aPKC)/FoxO1/c-Myc signalling contributes to excessive EC proliferation in angiosarcoma and when constitutively active, FoxO1 leads to lethality due to heart defects.
0.5 mg/ml. For use in WB (1:500), ELISA (1:1000) and IHC (1:100). Reacts with Human, rat, mouse. May also recognise the equivalent serine in FoxO3/4/6.

• Marque: Biosynth