Anti-OTULIN antibody - serum

Ref. 3D-CRB2005228

Informations sur le produit

• Nom: Anti-OTULIN antibody - serum

Description

The methionine 1 (M1)-specific deubiquitinase (DUB), OTULIN (linear ubiquitination-specific deubiquitinase ovarian tumour domain deubiquitinase with linear linkage specificity), acts as a negative regulator of nuclear factor κB signalling and immune homeostasis. OTULIN cleaves M1-linked polyUb with high specificity and efficiency and thus tightly regulates the linear ubiquitin chain assembly complex (LUBAC) which is responsible for catalysing the conjugation of linear methionine 1 (M1)-linked polyubiquitin (polyUb). OTULIN is also a negative regulator of tumour necrosis factor- α (TNF-α) signalling, it prevents auto-ubiquitination of LUBAC components at steady state, and the accumulation of M1-linked chains. OTULIN is critical for preventing spontaneous inflammation and maintaining immune homeostasis.
Serum. For use in WB (1:1000) and ELISA (1:1000). Reacts with Human.
Image: Anti-OTULIN antibody (crb2005228) (1:1000)
Western blot analysis of cell extract of HCT-116 human colon carcinoma cells wildtype and CRISPR-targeted (OTULIN-/-).
Lane 1: HCT-116 cells wildtype
Lane 2: HCT-116 cells CRISPR-targeted (OTULIN-/-)

• Marque: Biosynth