Anti-beta-Catenin antibody - 0.4mg/mL

Ref. 3D-CRB2005237

Informations sur le produit

• Nom: Anti-beta-Catenin antibody - 0.4mg/mL

Description

β-Catenin is a multifunctional protein that acts both as a transcriptional co-regulator and an adaptor protein for intracellular adhesion and is a vital component of the Wnt signalling pathway, an evolutionarily conserved pathway crucially involved in embryonic development and tissue homeostasis.

Wnt signalling pathway is the main regulator of β-catenin, when the pathway is not active, β-catenin is kept at a low level by the ubiquitin proteasome system (UPS). Following nuclear translocation via activation of the Wnt signalling pathway, β-catenin is thought to form a transcriptional complex with DNA binding proteins such as TCF/LEF, p300/CBP to help fulfil its role as a transcriptional activator.

Aberrant activation of Wnt signalling results in the accumulation of β-catenin in the nucleus and promotes the transcription of many oncogenes such as c-Myc and CyclinD-1. Indeed, once in the nucleus, β-catenin binds to several nuclear proteins involved in tumour development or progression such as p300/CBP, TATA-box binding protein (TBP), Pontin52, Reptin52, Brg-1, MUC1-C, SOX10, p68/p72, FOXM1, yes-associated protein 1 (YAP1) and FBW1. Over-expression of β-Catenin has been linked to various diseases including colon cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, skin cancer breast cancer and ovarian cancer.

Data: Anti-β-Catenin antibody (crb2005237) (1µg/ml).
Western blot analysis of whole cell extract human embryonic kidney cells HEK293 cells (30µg) and human prostate cancer CWR cells (30µg) .
Lane 1: HEK293 (30ug).
Lane 2: CWR (30ug.

• Marque: Biosynth