Anti-MKP1 antibody - 1mg/mL

Ref. 3D-CRB2005260

Informations sur le produit

• Nom: Anti-MKP1 antibody - 1mg/mL

Description

MAPK phosphatases (MKPs) are able to dephosphorylate both the threonine and tyrosine residues in conserved motifs, thereby inhibiting their activity.

MKP1 is a bispecific phosphatase and an anti-apoptotic protein that plays a key role in various physiological and pathological phenomena, including tumour metastasis and invasion. MKP1 acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK and is located in the nucleus.

MKP1 plays an important role in oncogenesis, tumour progression, and resistance to chemotherapy in cancers such as ovarian, lung, or breast and glioblastoma. Activation of MKP1 might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma.

Data: Institute of Cancer Research Western blot analysis of primary machrophages.
Lane 1:RM
Lane 2: BMDM untreated
Lane 3: 0.5µg/mlLPS 1hr treatment
Western blot image provided courtesy ofDr Rebecca Wilson

• Marque: Biosynth