Anti-TAS2R39 antibody - 2mg/mL

Ref. 3D-CRB2005729

Informations sur le produit

• Nom: Anti-TAS2R39 antibody - 2mg/mL

Description

Bitter taste receptors (TAS2Rs) are predominantly found in the mouth and other tissues, including the gut and lungs, and cell types such as immune cells. Â Taste receptor type 2 member 39 (TAS2R39) is a receptor that plays a prominent role in the perception of bitterness. TAS2R39 may also play a role in sensing the chemical composition of the gastrointestinal content. The activity of the TAS2R39 receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. TAS2Rs recognise a wide variety of compounds, and work with TAS2R39 has helped identify antagonist compounds to block the perceived bitterness of medications. 6-methoxyflavanones are antagonists of TAS2R39, the methoxy group on the 6-position of the flavanone's A-ring is the critical region for exerting inhibitory activity.

TAS2Rs recognise bacterial compounds such as acyl-homoserine lactones and are active in neurogenic inflammation and bacterial clearance for the upper airways. In the lungs, bronchial muscle contraction and cilia beating on epithelial cells are modulated by TAS2R receptor activation. TAS2R agonists can inhibit lung inflammation or smooth muscle contraction in asthma animal models.

This polyclonal antibody is reactive to the human TAS2R39.

• Marque: Biosynth