Anti-Kat2 antibody - 2mg/mL

Ref. 3D-CRB2005730

Informations sur le produit

• Nom: Anti-Kat2 antibody - 2mg/mL
• Marque: Biosynth
• Description: Kynurenine aminotransferase (Kat) enzymes convert Kynurenine (KYN) to kynurenic acid (KYNA) as part of the oxidative metabolism of tryptophan. KYNA is an endogenous antagonist of glutamate in the central nervous system. It is most active as an antagonist at receptors sensitive to N-methyl-D-aspartate (NMDA), which regulates neuronal excitability, plasticity, brain development, and behaviour. KYNA is also thought to play a causative role in hypo-glutamatergic conditions such as schizophrenia and a protective role in several neurodegenerative disorders, notably Huntington's disease. Of the 4 isoforms, Kat2 is the most active. Kat2 is a member of the Class-I pyridoxal-phosphate-dependent aminotransferase family. Kat2 is primarily located in brain tissue, believed to be in the mitochondria; accumulation of KYNA has been associated with schizophrenia. Selective inhibitors of Kat2 are being investigated as therapeutic targets for the management of schizophrenia and cognitive impairment.