AF488 Anti-Phospho-GluR2 (pS880) antibod - 0.25mg/mL

Ref. 3D-CRB2115005

Informations sur le produit

• Nom: AF488 Anti-Phospho-GluR2 (pS880) antibod - 0.25mg/mL
• Synonymes: Alexa Fluor ® 488 Anti-Phospho-GluR2 (pS

Description

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers._x000D_
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The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs. Phosphorylation of AMPARs is often implicated in synaptic plasticity and the pathological signalling seen in several disease states. Phosphorylation of GluR2 on serine 880 is involved in changes of synaptic efficacy where it regulates GluR2 synaptic recycling, AMPA signalling strength and plasticity._x000D_
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This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.

• Marque: Biosynth

Propriétés chimiques

• Degré de pureté: Min. 95%