AF488 Anti-HAND-1 antibody - 0.69mg/mL

Ref. 3D-CRB2115015

Informations sur le produit

• Nom: AF488 Anti-HAND-1 antibody - 0.69mg/mL
• Synonymes: Alexa Fluor ® 488 Anti-HAND-1 antibody
• Marque: Biosynth
• Description: Heart and neural crest derivatives expressed 1 (HAND1) is a basic helix-loop-helix (bHLH) transcription factor belonging to the twist family. Twist-family transcription factors play essential roles in a number of developmental programs and function by dimerising with other bHLH members and binding to cis- regulatory elements, called E-boxes. HAND1 can form homodimers as well as interact with other tissue restricted bHLH proteins, such as HAND2. Dimer partner choice infers differential regulation on twist family proteins and is regulated by phosphorylation. Protein Kinase A and C (PKA and PKC) can phosphorylate HAND1, while β56ÎŽ-containing protein phosphatase 2A (PP2A) can dephosphorylate HAND1._x000D__x000D_HAND1 is required for proper cardiac morphogenesis and is essential for extra-embryonic and trophoblast cell differentiation. Hand1 is expressed in several foetal tissues and in adult heart tissue where it may have a role in preventing hypertrophy._x000D__x000D_This antibody has Alexa Fluor® 488 conjugated to it. Alexa Fluor® 488 is a popular bright green fluorescent dye with high PH-stability.

Propriétés chimiques

• Degré de pureté: Min. 95%