Maritoclax
CAS : 1227962-62-0
Ref. 3D-CZB96262
| 5mg | À demander | ||
| 10mg | À demander | ||
| 25mg | À demander | ||
| 50mg | À demander | ||
| 100mg | À demander |
Informations sur le produit
- 1,1'-(4,4',5,5'-Tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl)bis[1-(2-hydroxyphenyl)methanone]
Maritoclax is a low-potency, selective inhibitor of the mcl-1 protein. It has been shown to increase the sensitivity of leukemia cells to chemotherapy by inducing apoptosis in leukemia cells that express wild-type mcl-1 and chemoresistance in those that have mutated the protein. Maritoclax has also been shown to be effective against skin cancer in vivo, where it inhibits proliferation and induces apoptosis. In addition, maritoclax can induce apoptosis in primary cells from human patients with autoimmune diseases such as systemic lupus erythematosus.
Mutations in cyclin D2 may lead to resistance to maritoclax treatment because the drug only works on cells with wild-type cyclin D2 expression. This drug may also be synergistic with other drugs that target cell proliferation, such as gemcitabine or cetuximab.
Propriétés chimiques
Question d’ordre technique sur : 3D-CZB96262 Maritoclax
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