ZB716

CAS : 1853279-29-4

Ref. 3D-DZC27929

Informations sur le produit

• Nom: ZB716
• Synonymes: Boronic acid, B-[(7α,17β)-17-hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl]-, ZB 716, Fulvestrant-3-boronic Acid, B-[(7α,17β)-17-Hydroxy-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3-yl]boronic acid

Description

ZB716 is a novel, orally bioavailable compound that inhibits the activity of CDK4/6 and shows promise in the treatment of cancers. It has been shown to inhibit tumor growth in xenograft models. ZB716 is a selective CDK4/6 inhibitor that binds to the ATP pocket on both CDK4 and CDK6, preventing phosphorylation and downstream activation of these kinases. This inhibition causes cell cycle arrest at the G2-M phase transition and inhibits cell growth. ZB716 has been shown to reduce estrogen receptor modulators in human liver samples via competitive inhibition.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 634.6 g/mol
• Formule: C₃₂H₄₈BF₅O₄S
• Degré de pureté: Min. 95%