AM 2201

CAS : 335161-24-5

Ref. 3D-FA17340

Informations sur le produit

• Nom: AM 2201
• Synonymes: [1-(5-Fluoropentyl)-1H-indol-3-yl]-1-naphthalenylmethanone[1-(5-Fluoropentyl)-3-(naphthalen-1-oyl)indole
• Marque: Biosynth

Description

AM-2201 is a potent, non-selective synthetic cannabinoid of the aminoalkylindole type which acts as a full agonist at cannabinoid receptors CB1 and CB2 (EC50 = 38 nM and 58 nM, respectively)1. AM-2201 metabolites are also recognised to be full agonists1. Binding to the cannabinoid receptors triggers a reduction of intracellular cAMP levels by inhibiting adenylate cyclase2. In vitro studies have shown 41 and 18 times more affinity for CB1 and CB2 receptors, respectively, when compared to Δ9-THC and revealed dosage-dependent cytotoxicity and chromosomal aberrations in primary cell lines3. Studies on experimental mice models showed bradycardia, hypothermia, and catalepsy1.

Propriétés chimiques

• Masse moléculaire: 359.44 g/mol
• Formule: C₂₄H₂₂FNO
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2
• Code InChI: InChIKey=ALQFAGFPQCBPED-UHFFFAOYSA-N
• SMILES: O=C(c1cccc2ccccc12)c1cn(CCCCCF)c2ccccc12