α-L-Iduronidase, recombinant, lyophilised

CAS : 9073-56-7

Ref. 3D-FA181881

Informations sur le produit

• Nom: α-L-Iduronidase, recombinant, lyophilised
• Synonymes: IDUA, α-L-Iduronidase

Description

PAIRED PRODUCTS AVAILABLE:

4-MU-alpha-L-idopyranosiduronic acid 2-sulphate, Substrate, EM03201
4MU-alpha-L-idopyranosiduronic acid, Substrate, EM04841

Alpha-L-iduronidase is a glycoside hydrolase that cleaves the non-reducing, terminal alpha-L-iduronic acid residues from polysaccharides and oligosaccharides. Alpha-L-iduronidase is involved in the lysosomal degradation of glycosaminoglycans and its deficiency leads to the accumulation of dermatan sulphate and heparan sulphate in tissues, a condition known as mucopolysaccharidosis I (MPS I). Alpha-L-iduronidase activity can be detected and quantified in an assay using a fluorogenic substrate 4MU-alpha-L-idopyranosiduronic acid. Alpha-L-iduronidase is also used in a 2-step assay for Hunter syndrome (MPS II) testing in combination with 4-MU-alpha-L-idopyranosiduronic acid 2-sulphate.
This enzyme is supplied as a lyophilisate of: 25% (w/w) Iduronidase enzyme (protein), 37% (w/w) sucrose, 38% (w/w) MOPS potassium (buffer, pH 7.4). The enzyme is derived from a bacterial source, recombinantly expressed in Escherichia coli (see application notes for more details). Alpha-L-iduronidase is also available as an aqueous solution (FI179383)

• Marque: Biosynth

Propriétés chimiques

• Degré de pureté: Corresponds To Requirements
• Couleur/Forme: Powder