2-Aminochrysene

CAS : 789-47-9

Ref. 3D-FA66865

Informations sur le produit

• Nom: 2-Aminochrysene
• Synonymes: Ai3-52508, Brn 2806929, Ccris 6985, Nsc 14764, 2-Chrysenamine, Chrysen-2-Amine

Description

2-Aminochrysene is a chemical that binds to DNA and causes a genotoxic effect. It has been shown to be carcinogenic to rats and is carcinogenic in humans. 2-Aminochrysene is metabolized by conjugation with glucuronic acid or glutathione, which are found in the liver, kidney, and other tissues. The binding constants for 2-aminochrysene were measured using the calf thymus DNA as a substrate and amines as ligands. Transfer of 2-aminochrysene from the plasma membrane to the cytosol was observed in cells treated with nitrous oxide (NO). The cytosolic enzyme binding assay showed that 2-aminochrysene binds to the S9 protein of hepatic microsomes.
2-Aminochrysene has also been shown to inhibit phospholipase A2 activity, which may be due to its ability to bind to the enzyme's active site.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 243.3 g/mol
• Formule: C₁₈H₁₃N
• Degré de pureté: Min. 95%
• Couleur/Forme: Yellow Powder
• InChI: InChI=1S/C18H13N/c19-14-7-10-16-13(11-14)6-9-17-15-4-2-1-3-12(15)5-8-18(16)17/h1-11H,19H2
• Code InChI: InChIKey=KSDIHKMNSYWRFB-UHFFFAOYSA-N
• SMILES: Nc1ccc2c(ccc3c4ccccc4ccc23)c1