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Ammonium trifluoromethanesulfonate is a proton-donating agent that influences insulin sensitivity. This compound has been shown to increase insulin sensitivity in humans by modulating the transport properties of insulin through the cell membrane. Ammonium trifluoromethanesulfonate also improves glucose utilization and inhibits hepatic gluconeogenesis. Insulin resistance is a condition in which cells do not respond properly to insulin, leading to high levels of blood glucose. Ammonium trifluoromethanesulfonate may be an effective treatment for diabetes and obesity due to its effects on insulin resistance.