BIBX 1382

CAS : 196612-93-8

Ref. 3D-FB102671

Informations sur le produit

• Nom: BIBX 1382
• Synonymes: Falnidamol, Bibx-1382, Bibx-1382Bs, N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine, N~8~-(3-chloro-4-fluorophenyl)-N~2~-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine

Description

BIBX 1382 is a potent inhibitor of the epidermal growth factor receptor (EGFR) and has been shown to be active against solid tumours in cell culture. BIBX 1382 binds to the ATP-binding pocket of the EGFR kinase domain and inhibits the activation of this domain. This inhibition prevents the phosphorylation of downstream proteins, such as tyrosine kinases, which are required for cellular proliferation. BIBX 1382 has low bioavailability due to its poor solubility in water and a high degree of protein binding.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 387.84 g/mol
• Formule: C₁₈H₁₉ClFN₇
• Degré de pureté: Min. 95%