Informations sur le produit
Nom :
1-Benzoylpiperazine
Synonymes :
- Chembrdg-Bb 5108505
- Akos Bb-6352
- Phenyl-Piperazin-1-Yl-Methanone
- N-Benzoylpiperazine
- 1-Benzoyl-Piperazine
- 1-Benzotriazolemonhydate Chem-4170
- 4-(Phenylcarbonyl)Piperazin-1-Ium
Description :
1-Benzoylpiperazine is a prodrug that is converted by esterases to its active form, 1-benzylpiperazine. It has been shown to have potent inhibitory activity against the growth of human cancer cells and was found to be more potent than piperazine in vitro. A molecular modeling study revealed that 1-benzoylpiperazine binds to the active site of monoacylglycerol lipase (MAGL) with high affinity and inhibits its enzymatic activity. The binding site for 1-benzoylpiperazine on MAGL is different from that of other inhibitors, such as phenylbutazone or indomethacin. The activation energies for 1-benzoylpiperazine binding were calculated using thermodynamic parameters derived from nmr spectra and are reported in kcal/mol.
Avis:
Nos produits sont destinés uniquement à un usage en laboratoire. Pour tout autre usage, veuillez nous contacter.
Marque:
Biosynth
Stockage à long terme :
Notes :
Propriétés chimiques
Masse moléculaire :
190.24 g/mol
Formule :
C11H14N2O
Degré de pureté :
Min. 95%
InChI :
InChI=1S/C11H14N2O/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13/h1-5,12H,6-9H2
Code InChI :
InChIKey=VUNXBQRNMNVUMV-UHFFFAOYSA-N
SMILES :
O=C(c1ccccc1)N1CCNCC1
MDL:
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