1-Benzoylpiperazine

CAS : 13754-38-6

Ref. 3D-FB37816

Informations sur le produit

• Nom: 1-Benzoylpiperazine
• Synonymes: Chembrdg-Bb 5108505, Akos Bb-6352, Phenyl-Piperazin-1-Yl-Methanone, N-Benzoylpiperazine, 1-Benzoyl-Piperazine, 1-Benzotriazolemonhydate Chem-4170, 4-(Phenylcarbonyl)Piperazin-1-Ium

Description

1-Benzoylpiperazine is a prodrug that is converted by esterases to its active form, 1-benzylpiperazine. It has been shown to have potent inhibitory activity against the growth of human cancer cells and was found to be more potent than piperazine in vitro. A molecular modeling study revealed that 1-benzoylpiperazine binds to the active site of monoacylglycerol lipase (MAGL) with high affinity and inhibits its enzymatic activity. The binding site for 1-benzoylpiperazine on MAGL is different from that of other inhibitors, such as phenylbutazone or indomethacin. The activation energies for 1-benzoylpiperazine binding were calculated using thermodynamic parameters derived from nmr spectra and are reported in kcal/mol.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 190.24 g/mol
• Formule: C₁₁H₁₄N₂O
• Degré de pureté: Min. 95%
• InChI: InChI=1S/C11H14N2O/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13/h1-5,12H,6-9H2
• Code InChI: InChIKey=VUNXBQRNMNVUMV-UHFFFAOYSA-N
• SMILES: O=C(c1ccccc1)N1CCNCC1