CCT 241533 hydrochloride

CAS : 1431697-96-9

Ref. 3D-FC104262

Informations sur le produit

• Nom: CCT 241533 hydrochloride
• Synonymes: 3-Pyrrolidinemethanol, 4-[[2-(5-fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-, hydrochloride (1:1), (3R,4S)-rel-

Description

Potent and specific inhibitor of checkpoint kinase CHK2 with IC50 of 3 nM. CCT 241533 binds to the ATP pocket of CHK2 and shows minimal cross-reactivity against related kinases. CCT 241533 blocked the activity of CHK2 and impaired DNA repair in response to DNA damage in human tumoral cell lines. The compound did not potentiate genotoxicity of several genotoxic compounds but it did potentiate the cytotoxicity of a PARP inhibitor olaparib.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 478.94 g/mol
• Formule: C₂₃H₂₇FN₄O₄•HCl
• Degré de pureté: Min. 95%