Cinchonine

CAS : 118-10-5

Ref. 3D-FC11047

Informations sur le produit

• Nom: Cinchonine
• Synonymes: 4-Quinolyl(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol, (3alpha,9R)-cinchonan-9-ol, (3alpha,9S)-cinchonan-9-ol, (4beta,9S)-cinchonan-1-ium-9-ol, (8R,9S)-Cinchonine, (8alpha,9S)-cinchonan-9-ol, (9R)-cinchonan-9-ol, (9S)-9-hydroxycinchonan-1-ium, (9S)-cinchonan-9-ol, Alpha-(5-Vinyl-2-Quinuclidinyl)-4-Quinolinemethanol, Cinchonan-9-Ol, Cinchonan-9-ol, (9S)-, Cinchonin, Cinconina, Nsc 6176, d-Cinchonine

Description

Cinchonine is a natural compound that has been found to have anti-cancer properties. It has shown to inhibit the growth of xenograft tumors in mice, which may be due to its ability to inhibit P-glycoprotein (P-gp). Cinchonine is metabolized by CYP2D6 and CYP3A4, with tiglic acid being the main metabolite. Cinchonine also has pro-apoptotic effects on HL60 cells and group P2 bowel disease. It has a structural analysis that includes an acetyl group at position 3 and methyl groups at positions 2 and 4. The reaction solution for cinchonine is shown below: Cinchonine can be synthesized from two molecules of pyridine via a condensation reaction with tiglic acid to form the intermediate nitrile followed by hydrolysis of the nitrile group with sodium hydroxide.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 294.39 g/mol
• Formule: C₁₉H₂₂N₂O
• Degré de pureté: Min. 95%