5'-Carboxy meloxicam

CAS : 130262-93-0

Ref. 3D-FC19734

Informations sur le produit

• Nom: 5'-Carboxy meloxicam
• Synonymes: 2-[[(4-Hydroxy-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-3-yl)carbonyl]amino]-5-thiazolecarboxylic acid, 2H-1,2-Benzothiazine, 5-thiazolecarboxylic acid deriv., 5-Thiazolecarboxylic acid, 2-[[(4-hydroxy-2-methyl-1,1-dioxido-2H-1,2-benzothiazin-3-yl)carbonyl]amino]-, 5-Thiazolecarboxylic acid, 2-[[(4-hydroxy-2-methyl-2H-1,2-benzothiazin-3-yl)carbonyl]amino]-, S,S-dioxide, 5i-Carboxy Meloxicam

Description

5'-Carboxy meloxicam is a prodrug of meloxicam that has been shown to be more bioavailable than the parent drug. The conversion of 5'-carboxy meloxicam to meloxicam in vivo is catalyzed by plasma esterases and carboxylesterases. The conversion is not affected by the presence of drugs that inhibit or induce these enzymes, such as other non-steroidal anti-inflammatory drugs (NSAIDs) or anticonvulsants. 5'-Carboxy meloxicam has been shown to be effective for pain control in both rats and humans. It has also been found to have less gastrointestinal side effects than other NSAIDs, such as ibuprofen, due to its lower concentration in plasma.
5'-Carboxy meloxicam is metabolized slowly and primarily excreted unchanged in urine with a half life of 10 hours. A pharmacokinetic study revealed that the oral dosage of 5'-carboxym

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 381.39 g/mol
• Formule: C₁₄H₁₁N₃O₆S₂
• Degré de pureté: Min. 95%
• Couleur/Forme: Brown Solid
• InChI: InChI=1S/C14H11N3O6S2/c1-17-10(12(19)16-14-15-6-8(24-14)13(20)21)11(18)7-4-2-3-5-9(7)25(17,22)23/h2-6,18H,1H3,(H,20,21)(H,15,16,19)
• Code InChI: InChIKey=MTQQFYLGAZXHTB-UHFFFAOYSA-N
• SMILES: CN1C(C(=O)Nc2ncc(C(=O)O)s2)=C(O)c2ccccc2S1(=O)=O