DIC

CAS : 693-13-0

Ref. 3D-FD02073

Informations sur le produit

• Nom: DIC
• Synonymes: 1,3-Diisopropylcarbodiimide N,N'-Diisopropylcarbodiimide, (E)-dipropan-2-yldiazene, (Propan-2-yl)([[(propan-2-yl)imino]methylidene])amine, 1,3-Diisopropylcarbodiimide, 2-Propanamine, N,N'-methanetetraylbis-, Carbodiimide, diisopropyl-, Carbodimide, N,N'-Diisopropyl-, Diisopropyl-Carbodiimid, Diisopropylcarbodiimide, Dipc, Dipcdi, Dipci, N,N'-Diisopropyl carbodiimide, N,N'-Methanetetraylbis(1-methylethylamine), N,N'-Methanetetraylbis(2-propanamine), N,N'-Methantetraylbis(1-methylethylamin), N,N'-dipropan-2-ylcarbodiimide, N,N'-metanotetrailbis(1-metiletilamina), N,N′-Diisopropylmethanediimine, Nsc 42080, PCI, N,N′-Diisopropylcarbodiimide

Description

DIC is a carbodiimide used as a coupling reagent for amide and ester formation, widely employed in peptide synthesis in presence of additives such as HOBt or HOAt to supress racemisation. Being a liquid, DIC is easier to handle than the solid DCC and forms a DCM-soluble urea by-product, while DCC generates a urea by-product insoluble in most organic solvents. Since the presence of insoluble urea is reportedly problematic in solid-phase peptide synthesis, for this application DIC is more suitable than DCC. A possible side-reaction with DIC and carbodiimides in general is the formation of an N-acylurea, which can be limited by conducting the reaction in DCM or chloroform at low temperatures, and by adding the amine at last.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 126.2 g/mol
• Formule: C₇H₁₄N₂
• Degré de pureté: Min. 99.0%
• Couleur/Forme: Colorless Clear Liquid
• InChI: InChI=1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
• Code InChI: InChIKey=BDNKZNFMNDZQMI-UHFFFAOYSA-N
• SMILES: CC(C)N=C=NC(C)C