4,6-Dichloronicotinaldehyde

CAS : 1060811-62-2

Ref. 3D-FD143587

Informations sur le produit

• Nom: 4,6-Dichloronicotinaldehyde
• Synonymes: 4,6-dichloro-3-Pyridinecarboxaldehyde, 4,6-Dichloropyridine-3-carboxaldehyde

Description

4,6-Dichloronicotinaldehyde is a potent inhibitor of the enzyme kinase Plk1. It inhibits the activity of this enzyme by binding to the ATP-binding site, thereby blocking ATP hydrolysis and inhibiting cell division. The IC50 for 4,6-dichloronicotinaldehyde is in the nanomolar range. This compound has been shown to inhibit cells with a specific phenotype, such as human mammary epithelial cells (HMEC), while not affecting other cell types such as HeLa cells. 4,6-Dichloronicotinaldehyde has also been shown to be effective against low nanomolar concentrations of Plk1 in vitro and in vivo.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 176 g/mol
• Formule: C₆H₃Cl₂NO
• Degré de pureté: Min. 95%
• Couleur/Forme: Solid
• InChI: InChI=1S/C6H3Cl2NO/c7-5-1-6(8)9-2-4(5)3-10/h1-3H
• Code InChI: InChIKey=AKYJFAHYRMPRDS-UHFFFAOYSA-N
• SMILES: O=Cc1cnc(Cl)cc1Cl