Larotrectinib
CAS :
Ref. 3D-FD145150
Informations sur le produit
Nom:Larotrectinib
Synonymes :
- LOXO 101(3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamideARR Y 470
Marque:Biosynth
Description :A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.
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Propriétés chimiques
Masse moléculaire :428.44 g/mol
Formule :C21H22F2N6O2
Degré de pureté :Min. 98 Area-%
Couleur/Forme :Yellow Powder
InChI :InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1
Code InChI :InChIKey=NYNZQNWKBKUAII-KBXCAEBGSA-N
SMILES :O=C(Nc1cnn2ccc(N3CCC[C@@H]3c3cc(F)ccc3F)nc12)N1CC[C@H](O)C1