2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one
CAS : 22288-77-3
Ref. 3D-FD21449
1g | Arrêté | ||
2g | Arrêté | ||
5g | Arrêté |
Informations sur le produit
- 2,5-Diamino-thiazolo[4,5-d]pyrimidin-7(4H)-one
2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one is an inhibitor of nucleoside phosphorylase. It has been shown to inhibit the growth of myeloid leukemia cells in culture. This drug may have a potential use in the treatment of T-cell leukemia and other malignancies involving purine metabolism. 2,5-Diamino-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one is an analogue of 8-aminoguanine (8AG), which is a substrate for nucleoside phosphorylase. The enzyme converts 8AG into guanosine triphosphate (GTP) and purine nucleosides. The enzyme also converts purine nucleosides into their corresponding ribonucleotides. These ribonucleotides are