2,4-Diamino-6-hydroxy-5-nitropyrimidine

CAS : 3346-23-4

Ref. 3D-FD21462

Informations sur le produit

• Nom: 2,4-Diamino-6-hydroxy-5-nitropyrimidine
• Synonymes: 2,6-Diamino-5-nitroso-4-pyrimidinolNsc44924, 2,6-Diamino-5-nitropyrimidin-4(3H)-one, 4(3H)-pyrimidinone, 2,6-diamino-5-nitro-

Description

2,4-Diamino-6-hydroxy-5-nitropyrimidine is an anticancer agent that has been shown to be effective against both bone and colorectal cancers. It inhibits the growth of cancer cells by inducing caspase-independent cell death, which occurs in a pd-l1 dependent manner. This agent also has minimal toxicity in vitro, as it induces cell lysis at high concentrations. 2,4-Diamino-6-hydroxy-5-nitropyrimidine is not active against normal cells.
2,4-Diamino-6-hydroxy-5-nitropyrimidine induces mitochondrial membrane depolarization and mitochondrial membrane potential loss in a dose dependent manner. These effects are likely responsible for the induction of caspase independent cell death seen with this drug.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 171.11 g/mol
• Formule: C₄H₅N₅O₃
• Degré de pureté: Min. 95%
• Couleur/Forme: Yellow Powder