10-DEBC hydrochloride

CAS : 925681-41-0

Ref. 3D-FD29857

Informations sur le produit

• Nom: 10-DEBC hydrochloride
• Synonymes: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
• CAS: 925681-41-0

Description

10-Deoxy-10-β-D-arabinofuranosylcytosine (10-DEBC) is a chemotherapeutic drug that is used to treat cancers and degenerative diseases. 10-DEBC is an analog of deoxycytidine and it inhibits the synthesis of DNA by competitively inhibiting the ATP binding cassette transporter, leading to cell death by apoptosis or autophagy. It has been shown to be active against B16 mouse melanoma cells in vitro, as well as atp-binding cassette transporter positive cancer cells in vivo. 10-DEBC also inhibits glycogen synthase kinase 3 (GSK3), which regulates autophagy and apoptotic cell death. 10-DEBC has been shown to induce apoptotic cell death in Caco2 cells, a type of human colon adenocarcinoma cell line.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 381.34 g/mol
• Formule: C₂₀H₂₅N₂OCl·HCl
• Degré de pureté: Min. 95%
• Couleur/Forme: White Powder