Mertansine

CAS : 139504-50-0

Ref. 3D-FD33453

Informations sur le produit

• Nom: Mertansine
• Synonymes: N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine DM 1Maytansinoid DM 1, DM 1, N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)maytansine, Maytansine, N2′-deacetyl-N2′-(3-mercapto-1-oxopropyl)-, Maytansinoid DM 1

Description

N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine is a thiol-containing derivative of maytansine. Maytansine and its derivatives kill cells by interfering with the formation of microtubules, and causing the depolymerisation of already formed microtubules. Antibody conjugates of N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine and the murine monoclonal antibody TA. 1, using linkers containing either a disulfide bond or a thioether bond, have been synthesised. These antibody conjugates bind to the HER-2/new oncogene protein that is expressed on human breast tumor cells.

• Marque: Biosynth

Propriétés chimiques

• Masse moléculaire: 738.29 g/mol
• Formule: C₃₅H₄₈ClN₃O₁₀S
• Degré de pureté: Min. 95%
• Couleur/Forme: White Off-White Yellow Powder